SLITRK1 SLIT and NTRK like family member 1
Gene ID: 114798, updated on 20-Apr-2024Gene type: protein coding
Also known as: TTM; LRRC12
- See all available tests in GTR for this gene
- Go to complete Gene record for SLITRK1
- Go to Variation Viewer for SLITRK1 variants
Summary
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. GeneReviews: Not available | |
| Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. GeneReviews: Not available | |
| Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. GeneReviews: Not available | |
| Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. GeneReviews: Not available | |
| Tourette syndrome | See labs |
| Trichotillomania | See labs |
Genomic context
- Location:
- 13q31.1
- Sequence:
- Chromosome: 13; NC_000013.11 (83877205..83882474, complement)
- Total number of exons:
- 2
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for SLITRK1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SLITRK1 database
- Variation ViewerRelated Variants
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