C8orf34 chromosome 8 open reading frame 34
Gene ID: 116328, updated on 5-Mar-2024Gene type: protein coding
Also known as: VEST1; VEST-1
- See all available tests in GTR for this gene
- Go to complete Gene record for C8orf34
- Go to Variation Viewer for C8orf34 variants
Summary
This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer. GeneReviews: Not available | |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available | |
| Wnt signaling and Dupuytren's disease. GeneReviews: Not available |
Genomic context
- Location:
- 8q13.2
- Sequence:
- Chromosome: 8; NC_000008.11 (68330373..68819023)
- Total number of exons:
- 16
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for C8orf34 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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