ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
Gene ID: 127, updated on 11-Apr-2024Gene type: protein coding
Also known as: ADH-2; HEL-S-4
- See all available tests in GTR for this gene
- Go to complete Gene record for ADH4
- Go to Variation Viewer for ADH4 variants
Summary
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. GeneReviews: Not available | |
| Genetic determinants influencing human serum metabolome among African Americans. GeneReviews: Not available | |
| Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. GeneReviews: Not available |
Genomic context
- Location:
- 4q23
- Sequence:
- Chromosome: 4; NC_000004.12 (99123658..99144297, complement)
- Total number of exons:
- 10
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for ADH4 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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