CSNK1A1 casein kinase 1 alpha 1
Gene ID: 1452, updated on 7-Apr-2024Gene type: protein coding
Also known as: CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
- See all available tests in GTR for this gene
- Go to complete Gene record for CSNK1A1
- Go to Variation Viewer for CSNK1A1 variants
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. GeneReviews: Not available |
Genomic context
- Location:
- 5q32
- Sequence:
- Chromosome: 5; NC_000005.10 (149492982..149551439, complement)
- Total number of exons:
- 11
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CSNK1A1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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