CX3CR1 C-X3-C motif chemokine receptor 1

Gene ID: 1524, updated on 11-Apr-2024
Gene type: protein coding
Also known as: V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1

Summary

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Age related macular degeneration 12 MedGen: C3151079OMIM: 613784GeneReviews: Not available	See labs
Coronary heart disease, susceptibility to, 1 MedGen: C1846418OMIM: 607339GeneReviews: Not available	See labs
Susceptibility to HIV infection MedGen: C1836230OMIM: 609423GeneReviews: Not available	See labs

Genomic context

Location:: 3p22.2

Sequence:: Chromosome: 3; NC_000003.12 (39263494..39292966, complement)

Total number of exons:: 6

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for CX3CR1 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
CX3CR1 database
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

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