DGKQ diacylglycerol kinase theta
Gene ID: 1609, updated on 11-Apr-2024Gene type: protein coding
Also known as: DAGK; DAGK4; DAGK7
- See all available tests in GTR for this gene
- Go to complete Gene record for DGKQ
- Go to Variation Viewer for DGKQ variants
Summary
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. GeneReviews: Not available | |
| Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. GeneReviews: Not available | |
| Genomewide association study for susceptibility genes contributing to familial Parkinson disease. GeneReviews: Not available | |
| Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. GeneReviews: Not available | |
| Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. GeneReviews: Not available |
Genomic context
- Location:
- 4p16.3
- Sequence:
- Chromosome: 4; NC_000004.12 (958887..973569, complement)
- Total number of exons:
- 25
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for DGKQ variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.