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AGTR1 angiotensin II receptor type 1

Gene ID: 185, updated on 11-Apr-2024
Gene type: protein coding
Also known as: AT1; AG2S; AT1B; AT1R; ATR1; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B

Summary

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Essential hypertension, genetic
MedGen: CN305331OMIM: 145500GeneReviews: Not available
See labs
Renal tubular dysgenesis of genetic origin
MedGen: C5681536OMIM: 267430GeneReviews: Not available
See labs

Genomic context

Location:
3q24
Sequence:
Chromosome: 3; NC_000003.12 (148697903..148743003)
Total number of exons:
5

Links

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