U.S. flag

An official website of the United States government

GTR Home > Genes

F2 coagulation factor II, thrombin

Gene ID: 2147, updated on 28-May-2023
Gene type: protein coding
Also known as: PT; THPH1; RPRGL2


This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]

Associated conditions

See all available tests in GTR for this gene

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
GeneReviews: Not available
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Congenital prothrombin deficiency
MedGen: C0272317OMIM: 613679GeneReviews: Not available
See labs
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Ischemic stroke
MedGen: C0948008OMIM: 601367GeneReviews: Not available
See labs
Pregnancy loss, recurrent, susceptibility to, 2
MedGen: C3280672OMIM: 614390GeneReviews: Not available
See labs
Thrombophilia due to thrombin defectSee labs

Genomic context

Chromosome: 11; NC_000011.10 (46719213..46739506)
Total number of exons:


IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.