ALOX5AP arachidonate 5-lipoxygenase activating protein
Gene ID: 241, updated on 29-Mar-2023Gene type: protein coding
Also known as: FLAP
- See all available tests in GTR for this gene
- Go to complete Gene record for ALOX5AP
- Go to Variation Viewer for ALOX5AP variants
Summary
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study for reading and language abilities in two population cohorts. GeneReviews: Not available | |
| A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. GeneReviews: Not available | |
| Ischemic stroke | See labs |
Genomic context
- Location:
- 13q12.3
- Sequence:
- Chromosome: 13; NC_000013.11 (30713485..30764426)
- Total number of exons:
- 7
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | GeneView ReportGo to Variation Viewer for ALOX5AP variants |
| 1000 Genomes | See 1000 Genomes Browser (GRCh37.p13) |
- ALOX5AP @ LOVD
- BioSystemsBioSystems
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SNP: GeneViewSNPs linked from GeneView
IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.