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ALOX5AP arachidonate 5-lipoxygenase activating protein

Gene ID: 241, updated on 29-Mar-2023
Gene type: protein coding
Also known as: FLAP


This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Associated conditions

See all available tests in GTR for this gene

A genome-wide association study for reading and language abilities in two population cohorts.
GeneReviews: Not available
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
GeneReviews: Not available
Ischemic stroke
MedGen: C0948008OMIM: 601367GeneReviews: Not available
See labs

Genomic context

Chromosome: 13; NC_000013.11 (30713485..30764426)
Total number of exons:


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