IFNL3 interferon lambda 3
Gene ID: 282617, updated on 11-Apr-2024Gene type: protein coding
Also known as: IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4
- See all available tests in GTR for this gene
- Go to complete Gene record for IFNL3
- Go to Variation Viewer for IFNL3 variants
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. GeneReviews: Not available | |
| Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. GeneReviews: Not available | |
| Hepatitis C virus, susceptibility to | See labs |
| IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. GeneReviews: Not available | |
| Peginterferon alfa-2a response MedGen: CN184128GeneReviews: Not available | See labs |
| Peginterferon alfa-2b response MedGen: CN078000GeneReviews: Not available | See labs |
| Ribavirin response MedGen: CN184129GeneReviews: Not available | See labs |
| Simeprevir response MedGen: CN236396GeneReviews: Not available | not available |
| Telaprevir response MedGen: CN078014GeneReviews: Not available | See labs |
Genomic context
- Location:
- 19q13.2
- Sequence:
- Chromosome: 19; NC_000019.10 (39243455..39245250, complement)
- Total number of exons:
- 6
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for IFNL3 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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