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IDH2 isocitrate dehydrogenase (NADP(+)) 2

Gene ID: 3418, updated on 17-Jan-2022
Gene type: protein coding
Also known as: IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH

Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Associated conditions

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DescriptionTests
D-2-hydroxyglutaric aciduria 2
MedGen: C3150909OMIM: 613657GeneReviews: Not available
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Genomic context

Location:
15q26.1
Sequence:
Chromosome: 15; NC_000015.10 (90083045..90102468, complement)
Total number of exons:
12

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