IL1R1 interleukin 1 receptor type 1
Gene ID: 3554, updated on 11-Apr-2024Gene type: protein coding
Also known as: P80; IL1R; CRMO3; IL1RA; CD121A; D2S1473; IL-1RT1; IL-1R-alpha
- See all available tests in GTR for this gene
- Go to complete Gene record for IL1R1
- Go to Variation Viewer for IL1R1 variants
Summary
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Chronic recurrent multifocal osteomyelitis 3 | not available |
| Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. GeneReviews: Not available | |
| Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids. GeneReviews: Not available | |
| Genome-wide association study to identify genetic determinants of severe asthma. GeneReviews: Not available | |
| Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. GeneReviews: Not available | |
| Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. GeneReviews: Not available |
Genomic context
- Location:
- 2q11.2-q12.1
- Sequence:
- Chromosome: 2; NC_000002.12 (102070390..102179874)
- Total number of exons:
- 21
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for IL1R1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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