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FASLG Fas ligand

Gene ID: 356, updated on 29-Jan-2023
Gene type: protein coding
Also known as: APTL; FASL; CD178; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1


This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

Associated conditions

See all available tests in GTR for this gene

Autoimmune lymphoproliferative syndrome type 1See labs
Autoimmune lymphoproliferative syndrome, type 1b
MedGen: C1866120GeneReviews: Not available
See labs
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Lung cancer
MedGen: C0242379OMIM: 211980GeneReviews: Not available
See labs
Lung carcinoma
MedGen: C0684249GeneReviews: Not available
See labs
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available

Genomic context

Chromosome: 1; NC_000001.11 (172659103..172666876)
Total number of exons:


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