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KRAS KRAS proto-oncogene, GTPase

Gene ID: 3845, updated on 17-Jan-2022
Gene type: protein coding
Also known as: NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2

Summary

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2015-10-08)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2015-10-08)

ClinGen Genome Curation Page

Genomic context

Location:
12p12.1
Sequence:
Chromosome: 12; NC_000012.12 (25205246..25250929, complement)
Total number of exons:
6

Links

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