KRAS KRAS proto-oncogene, GTPase

Gene ID: 3845, updated on 22-Apr-2024
Gene type: protein coding
Also known as: NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2

Summary

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Acute myeloid leukemia MedGen: C0023467OMIM: 601626GeneReviews: CEBPA-Associated Familial Acute Myeloid Leukemia (AML), ETV6 Thrombocytopenia and Predisposition to Leukemia, RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies, DDX41-Associated Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia	See labs
Autoimmune lymphoproliferative syndrome type 4 MedGen: C2674723OMIM: 614470GeneReviews: Not available	See labs
Carcinoma of pancreas MedGen: C0235974OMIM: 260350GeneReviews: Not available	See labs
Cardiofaciocutaneous syndrome 2 MedGen: C3809005OMIM: 615278GeneReviews: Cardiofaciocutaneous Syndrome	See labs
Cerebral arteriovenous malformation MedGen: C0917804OMIM: 108010GeneReviews: Not available	See labs
Cetuximab response MedGen: CN077967GeneReviews: Not available	See labs
Familial cancer of breast MedGen: C0346153OMIM: 114480GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	See labs
Gastric cancer MedGen: C0024623OMIM: 613659GeneReviews: Not available	See labs
Linear nevus sebaceous syndrome MedGen: C4552097OMIM: 163200GeneReviews: Not available	See labs
Lung cancer MedGen: C0242379OMIM: 211980GeneReviews: Not available	See labs
Malignant tumor of urinary bladder MedGen: C0005684OMIM: 109800GeneReviews: Not available	See labs
Noonan syndrome 3 MedGen: C1860991OMIM: 609942GeneReviews: Noonan Syndrome	See labs
Panitumumab response MedGen: CN077999GeneReviews: Not available	See labs
Toriello-Lacassie-Droste syndrome MedGen: C1838329OMIM: 600268GeneReviews: Not available	See labs

Genomic context

Location:: 12p12.1

Sequence:: Chromosome: 12; NC_000012.12 (25205246..25250929, complement)

Total number of exons:: 7

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for KRAS variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

Catalogue of Somatic Mutations in Cancer (COSMIC)
ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
KRAS database
MedGen
Related information in MedGen
NSEuroNet database - KRAS
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

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