MSMB microseminoprotein beta
Gene ID: 4477, updated on 5-Mar-2024Gene type: protein coding
Also known as: MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
- See all available tests in GTR for this gene
- Go to complete Gene record for MSMB
- Go to Variation Viewer for MSMB variants
Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genetic correction of PSA values using sequence variants associated with PSA levels. GeneReviews: Not available | |
| Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies. GeneReviews: Not available | |
| Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. GeneReviews: Not available | |
| Genome-wide association scan for variants associated with early-onset prostate cancer. GeneReviews: Not available | |
| Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. GeneReviews: Not available | |
| Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. GeneReviews: Not available | |
| Genome-wide association study identifies genetic determinants of urine PCA3 levels in men. GeneReviews: Not available | |
| Genome-wide association study identifies new prostate cancer susceptibility loci. GeneReviews: Not available | |
| Genome-wide association study of hematological and biochemical traits in a Japanese population. GeneReviews: Not available | |
| Multiple loci identified in a genome-wide association study of prostate cancer. GeneReviews: Not available | |
| Multiple newly identified loci associated with prostate cancer susceptibility. GeneReviews: Not available | |
| Prostate cancer, hereditary, 13 | See labs |
Genomic context
- Location:
- 10q11.22
- Sequence:
- Chromosome: 10; NC_000010.11 (46033313..46046269, complement)
- Total number of exons:
- 4
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for MSMB variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- MSMB database
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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