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> MYC

MYC MYC proto-oncogene, bHLH transcription factor

Gene ID: 4609, updated on 16-Apr-2024
Gene type: protein coding
Also known as: MRTL; MYCC; c-Myc; bHLHe39

Summary

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
A common variant at 8q24.21 is associated with renal cell cancer.
GeneReviews: Not available
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
GeneReviews: Not available
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
GeneReviews: Not available
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
GeneReviews: Not available
Burkitt lymphoma
MedGen: C0006413OMIM: 113970GeneReviews: Not available
See labs
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
GeneReviews: Not available
Genome-wide association scan for variants associated with early-onset prostate cancer.
GeneReviews: Not available
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
GeneReviews: Not available
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
GeneReviews: Not available
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
GeneReviews: Not available
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.
GeneReviews: Not available
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
GeneReviews: Not available
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
GeneReviews: Not available
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
GeneReviews: Not available
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
GeneReviews: Not available
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
GeneReviews: Not available

Genomic context

Location:
8q24.21
Sequence:
Chromosome: 8; NC_000008.11 (127735434..127742951)
Total number of exons:
3

Go to nucleotideGraphics FASTA GenBank

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