PDYN prodynorphin
Gene ID: 5173, updated on 3-Apr-2024Gene type: protein coding
Also known as: ADCA; PENKB; SCA23
- See all available tests in GTR for this gene
- Go to complete Gene record for PDYN
- Go to Variation Viewer for PDYN variants
Summary
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association study of antibody response to smallpox vaccine. GeneReviews: Not available | |
| Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. GeneReviews: Not available | |
| Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. GeneReviews: Not available | |
| Spinocerebellar ataxia type 23 | See labs |
Genomic context
- Location:
- 20p13
- Sequence:
- Chromosome: 20; NC_000020.11 (1978756..1994285, complement)
- Total number of exons:
- 9
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PDYN variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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