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RAD51C RAD51 paralog C

Gene ID: 5889, updated on 23-Nov-2023
Gene type: protein coding
Also known as: FANCO; R51H3; BROVCA3; RAD51L2


This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Associated conditions

See all available tests in GTR for this gene

Breast-ovarian cancer, familial, susceptibility to, 3
MedGen: C3150659OMIM: 613399GeneReviews: Not available
See labs
Fanconi anemia complementation group O
MedGen: C3150653OMIM: 613390GeneReviews: Fanconi Anemia
See labs
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
GeneReviews: Not available
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
GeneReviews: Not available
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
GeneReviews: Not available

Copy number response

Copy number response

No evidence available (Last evaluated 2020-07-08)

ClinGen Genome Curation Page

Sufficient evidence for dosage pathogenicity (Last evaluated 2020-07-08)

ClinGen Genome Curation PagePubMed

Genomic context

Chromosome: 17; NC_000017.11 (58692573..58735611)
Total number of exons:


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