ROS1 ROS proto-oncogene 1, receptor tyrosine kinase
Gene ID: 6098, updated on 11-Apr-2024Gene type: protein coding
Also known as: ROS; MCF3; c-ros-1
- See all available tests in GTR for this gene
- Go to complete Gene record for ROS1
- Go to Variation Viewer for ROS1 variants
Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. GeneReviews: Not available | |
| Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. GeneReviews: Not available |
Genomic context
- Location:
- 6q22.1
- Sequence:
- Chromosome: 6; NC_000006.12 (117287353..117425942, complement)
- Total number of exons:
- 46
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for ROS1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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