SCN10A sodium voltage-gated channel alpha subunit 10
Gene ID: 6336, updated on 3-Apr-2024Gene type: protein coding
Also known as: PN3; SNS; FEPS2; Nav1.8
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- Go to complete Gene record for SCN10A
- Go to Variation Viewer for SCN10A variants
Summary
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Associated conditions
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| Description | Tests |
|---|---|
| Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. GeneReviews: Not available | |
| Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. GeneReviews: Not available | |
| Episodic pain syndrome, familial, 2 | See labs |
| Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. GeneReviews: Not available | |
| Genetic determinants of P wave duration and PR segment. GeneReviews: Not available | |
| Genetic variation in SCN10A influences cardiac conduction. GeneReviews: Not available | |
| Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. GeneReviews: Not available | |
| Genome-wide association studies of the PR interval in African Americans. GeneReviews: Not available | |
| Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. GeneReviews: Not available | |
| Genome-wide association study of PR interval. GeneReviews: Not available | |
| Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. GeneReviews: Not available | |
| Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. GeneReviews: Not available | |
| Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. GeneReviews: Not available | |
| Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. GeneReviews: Not available | |
| Several common variants modulate heart rate, PR interval and QRS duration. GeneReviews: Not available |
Genomic context
- Location:
- 3p22.2
- Sequence:
- Chromosome: 3; NC_000003.12 (38696807..38816217, complement)
- Total number of exons:
- 28
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for SCN10A variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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