SFRP1 secreted frizzled related protein 1
Gene ID: 6422, updated on 11-Apr-2024Gene type: protein coding
Also known as: FRP; FRP1; FrzA; FRP-1; SARP2
- See all available tests in GTR for this gene
- Go to complete Gene record for SFRP1
- Go to Variation Viewer for SFRP1 variants
Summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Genomic context
- Location:
- 8p11.21
- Sequence:
- Chromosome: 8; NC_000008.11 (41261962..41309473, complement)
- Total number of exons:
- 3
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for SFRP1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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