WNT3 Wnt family member 3
Gene ID: 7473, updated on 5-Mar-2024Gene type: protein coding
Also known as: INT4; TETAMS
- See all available tests in GTR for this gene
- Go to complete Gene record for WNT3
- Go to Variation Viewer for WNT3 variants
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population. GeneReviews: Not available | |
| Identification of a novel Parkinson's disease locus via stratified genome-wide association study. GeneReviews: Not available | |
| Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. GeneReviews: Not available | |
| Multiple common variants for celiac disease influencing immune gene expression. GeneReviews: Not available | |
| Tetraamelia syndrome 1 | See labs |
Genomic context
- Location:
- 17q21.31-q21.32
- Sequence:
- Chromosome: 17; NC_000017.11 (46762506..46818692, complement)
- Total number of exons:
- 5
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for WNT3 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
- WNT3 database
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