PSCA prostate stem cell antigen
Gene ID: 8000, updated on 5-Mar-2024Gene type: protein coding
Also known as: PRO232; lncPSCA
- See all available tests in GTR for this gene
- Go to complete Gene record for PSCA
- Go to Variation Viewer for PSCA variants
Summary
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. GeneReviews: Not available | |
| A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. GeneReviews: Not available | |
| Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. GeneReviews: Not available | |
| Genome-wide association study identifies multiple loci associated with bladder cancer risk. GeneReviews: Not available |
Genomic context
- Location:
- 8q24.3
- Sequence:
- Chromosome: 8; NC_000008.11 (142670297..142682725)
- Total number of exons:
- 4
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PSCA variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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