MLLT10 MLLT10 histone lysine methyltransferase DOT1L cofactor

Gene ID: 8028, updated on 5-Mar-2024
Gene type: protein coding
Also known as: AF10

Summary

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Acute myeloid leukemia MedGen: C0023467OMIM: 601626GeneReviews: CEBPA-Associated Familial Acute Myeloid Leukemia (AML), ETV6 Thrombocytopenia and Predisposition to Leukemia, RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies, DDX41-Associated Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia	See labs
Common variation at 10p12.31 near MLLT10 influences meningioma risk. GeneReviews: Not available
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. GeneReviews: Not available
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. GeneReviews: Not available

Genomic context

Location:: 10p12.31

Sequence:: Chromosome: 10; NC_000010.11 (21533756..21743630)

Total number of exons:: 30

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for MLLT10 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
MLLT10 database
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

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