ARHGAP24 Rho GTPase activating protein 24
Gene ID: 83478, updated on 3-Apr-2024Gene type: protein coding
Also known as: p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP
- See all available tests in GTR for this gene
- Go to complete Gene record for ARHGAP24
- Go to Variation Viewer for ARHGAP24 variants
Summary
This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genetic determinants of P wave duration and PR segment. GeneReviews: Not available | |
| Genome-wide association study of PR interval. GeneReviews: Not available | |
| Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. GeneReviews: Not available | |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available | |
| Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. GeneReviews: Not available | |
| Several common variants modulate heart rate, PR interval and QRS duration. GeneReviews: Not available |
Genomic context
- Location:
- 4q21.23-q21.3
- Sequence:
- Chromosome: 4; NC_000004.12 (85475150..86002666)
- Total number of exons:
- 15
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for ARHGAP24 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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