SLC25A21 solute carrier family 25 member 21

Gene ID: 89874, updated on 5-Mar-2024
Gene type: protein coding
Also known as: ODC; ODC1; MTDPS18

Summary

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. GeneReviews: Not available
Mitochondrial DNA depletion syndrome 18 MedGen: C5394140OMIM: 618811GeneReviews: Not available	See labs

Genomic context

Location:: 14q13.3

Sequence:: Chromosome: 14; NC_000014.9 (36677921..37172606, complement)

Total number of exons:: 13

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for SLC25A21 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
Variation Viewer
Related Variants

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