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MAP3K14 mitogen-activated protein kinase kinase kinase 14

Gene ID: 9020, updated on 5-Jan-2022
Gene type: protein coding
Also known as: HS; NIK; HSNIK; FTDCR1B

Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available

Genomic context

Location:
17q21.31
Sequence:
Chromosome: 17; NC_000017.11 (45263119..45317048, complement)
Total number of exons:
17

Links

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