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GTR Home > Tests > Oncotype DX Breast Recurrence Score Assay

Overview

Test name

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Oncotype DX Breast Recurrence Score Assay

Purpose of the test

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This is a clinical test intended for Help: Predictive, Prognostic, Recurrence, Therapeutic management

Condition

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How to order

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Order URL Help: https://precisiononcology.exactsciences.com/healthcare-providers/treatment-determination/breast-cancer/oncotype-dx-breast-recurrence-score/how-to-order

Specimen source

Paraffin block

Methodology

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Molecular Genetics
RRNA analysis
RT-qPCR
  • Other
  • None/not applicable

Summary of what is tested

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Clinical utility

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Guidance for management

Clinical validity

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The Oncotype DX Breast Recurrence Score test result (the Recurrence Score value) has been significantly correlated with distant breast cancer recurrence, breast cancer-specific survival, disease-free-survival and overall survival. Several studies demonstrate the clinical utility of the Breast Recurrence Score for providing a comprehensive and individualized risk assessment for early-stage invasive breast cancer. More info on clinical validity, please visit: https://precisiononcology.exactsciences.com/healthcare-providers/treatment-determination/breast-cancer/oncotype-dx-breast-recurrence-score/clinical-evidence/clinical-overview. To see publications that detail analytical validity , please visit: https://www.exactsciences.com/publications/list?cancer_type=Breast%20Cancer&product_type=Product&product=Oncotype%20DX%20Breast%20Recurrence%20Score%C2%AE%20test

Citations

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Suggested reading

  • Cardoso et al., 2016
  • Ward et al., 2013
    Gene expression profiling and expanded immunohistochemistry tests to guide the use of adjuvant chemotherapy in breast cancer management: a systematic review and cost-effectiveness analysis.

Clinical resources

Practice guidelines

  • NICE, 2024
    UK NICE Guideline NG101, Early and locally advanced breast cancer: diagnosis and management, 2024
  • NCCN, 2023
    Breast Cancer, NCCN Guidelines Version 4.2022
  • NCCN, 2022
    Breast Cancer Screening and Diagnosis, NCCN, Version 1.2022
  • NICE, 2018
    Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer (DG34)
  • NICE, 2018
    Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer, NICE, 2018
  • NCCN, 2014
    National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Breast Cancer (See 2022 Update)
  • NICE, 2013
    DG10 Gene expression profiling and expanded immunohistochemistry tests for guiding adjuvant chemotherapy decisions in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostrat: information for the public
  • AHRQ, 2013
    Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)
  • NCCN, 2011
    NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.