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GTR Home > Tests > IFISH for Aneuploidy (Products of Conception)

Indication

This is a clinical test intended for Help: Diagnosis

Clinical summary

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A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy. [from HPO]

Inheritance pattern

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Sporadic

Conditions tested

Target population

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Patients who have had a spontaneous miscarriage, intrauterine fetal demise, or stillbirth for which there is no known cause. Chromosome abnormalities such as trisomy 16, monosomy X, and triploidy are common causes of pregnancy loss. Diagnosing a genetic abnormality as the cause of miscarriage allows for more accurate recurrence risk counseling, reduces parental feelings of guilt, and eliminates the need for further workup.

Citations

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Clinical validity

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Not provided

Clinical utility

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Establish or confirm diagnosis

Citations
  • Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: clinical experience with 4,500 specimens. - PubMed ID: 8488836

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