TP53 sequencing and deletion/duplication
GTR Test Accession: Help GTR000552479.1
Last updated in GTR: 2016-12-29
Last annual review date for the lab: 2023-04-17 Past due LinkOut
At a Glance
Adrenocortical carcinoma, pediatric; Breast cancer, early-onset; Breast neoplasm; ...
Genes (1): Help
TP53 (17p13.1)
Molecular Genetics - Deletion/duplication analysis: Multiplex Ligation-dependent Probe Amplification (MLPA); ...
Genetic testing for TP53 may be recommended to individuals with …
Not provided
Not provided
Ordering Information
Offered by: Help
Children's Hospital of Los Angeles, Center for Personalized Medicine
View lab's website
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
Lab contact: Help
Vandana Mehta, MSc, Genetic Analyst Specialist
+1 323-644-8528
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
The test requisition with sample requirements is available on our website. Please contact us at (877)543-9522 or email Vandana Mehta at with any questions.
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 6
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Total methods: 2
Method Category Help
Test method Help
Instrument *
Deletion/duplication analysis
Multiplex Ligation-dependent Probe Amplification (MLPA)
Sequence analysis of the entire coding region
Bi-directional Sanger Sequence Analysis
* Instrument: Not provided
Clinical Information
Test purpose: Help
Target population: Help
Genetic testing for TP53 may be recommended to individuals with a personal and/or family history of , Li-Fraumeni Syndrome, sarcomas, brain tumors, adrenocortical carcinomas, and early-onset breast cancer.
Recommended fields not provided:
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
The analytical sensitivity and specificity is about 99% for these tests
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.