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GTR Home > Tests > Whole Pharmacogenomics Scan

Overview

Test order codeHelp: Whole Pharmacogenomics Scan (WPS)

Test name

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Whole Pharmacogenomics Scan (WPS)

Purpose of the test

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This is a clinical test intended for Help: Drug Response, Predictive, Risk Assessment, Therapeutic management

Condition

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Click Indication tab for more information.

How to order

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Acceptable specimen sources are blood, extracted DNA (gDNA), saliva and buccal swab. Peripheral Whole Blood: 3-5mL in EDTA tube (lavender top). This is our preferred specimen type; Extracted DNA: 1ug DNA (please indicate sample source on test request form); Saliva: Use DNA Genotek Oragene DNA (OG-500) kit. Buccal swab: Collect using Copan hDNAFree FLOQSwabs (Cat# 50E010D01) or IsoHelix RapiDri Buccal swab with self-drying pouch (Cat# RD-01) according to manufacturer’s instructions. All samples should be shipped Sunday through Thursday (next day delivery only). Contact for availability of alternative shipping schedules and additional shipping requirements. Shipping is acceptable at ambient or refrigerated temperature. Any blood samples collected and not shipped immediately should be refrigerated and shipped overnight as soon as possible (less than 5-7 days after collection) to ensure specimen stability and quality.
Order URL Help: https://www.rprdx.com/testing/how-it-works/

Specimen source

Buccal swab
Isolated DNA
Peripheral (whole) blood
Saliva

Methodology

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Molecular Genetics
DDeletion/duplication analysis
Microarray
  • Affymetrix GeneTitan® MC
  • Affymetrix Gene Profiling Array cGMP U133 P2
TTargeted variant analysis
Microarray
  • Affymetrix GeneTitan® MC
  • Affymetrix GeneTitan® MC
  • Affymetrix Gene Profiling Array cGMP U133 P2

Summary of what is tested

Click Methodology tab for more information.

Clinical utility

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Guidance for selecting a drug therapy and/or dose

Citations
  • A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. - PubMed ID: 22990750
  • Development and use of active clinical decision support for preemptive pharmacogenomics. - PubMed ID: 23978487

Pre-emptive clinical implementation

Citations
  • PG4KDS: a model for the clinical implementation of pre-emptive pharmacogenetics. - PubMed ID: 24619595

Clinical validity

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To determine the diagnostic sensitivity, we utilized the manufacturer’s recommended input concentration and analysis QC thresholds. We demonstrated adherence to our validation threshold (i.e. ≥ 95% sensitivity) in detection of true positive results, with a false negative rate of ≤ 5%. To determine the diagnostic specificity, we utilized the manufacturer’s recommended input concentration and analysis QC thresholds. The PharmacoScan™ Assay demonstrated ≥ 99% sensitivity in detecting the correct genotypes of each sample tested.

Citations

Testing strategy

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This test ideally is utilized pre-emptively (prior to receiving drug medication) or as a reflex testing when an adverse reaction to a medication has been observed. 000 Acceptable specimen sources are blood, extracted DNA (gDNA), saliva and buccal swab. Peripheral Whole Blood: 3-5mL in EDTA tube (lavender top). This is our preferred specimen type; Extracted DNA: 1ug DNA (please indicate sample source on test request form); Saliva: Use DNA Genotek Oragene DNA (OG-500) kit. Buccal swab: Collect using Copan hDNAFree FLOQSwabs (Cat# 50E010D01) or IsoHelix RapiDri Buccal swab with self-drying pouch (Cat# RD-01) according to manufacturer’s instructions. All samples should be shipped Sunday through Thursday (next day delivery only). Contact for availability of alternative shipping schedules and additional shipping requirements. Shipping is acceptable at ambient or refrigerated temperature. Any blood samples collected and not shipped immediately should be refrigerated and shipped overnight as soon as possible (less than 5-7 days after collection) to ensure specimen stability and quality.

Test services

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  • Pharmacogenetics, Order code: WPS

Practice guidelines

  • CPIC, 2021
    Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy
  • DPWG, 2020
    Royal Dutch Pharmacists Association (KNMP). Dutch Pharmacogenetics Working Group (DPWG). Pharmacogenetic Guidelines [Internet]. Netherlands. Codeine - CYP2D6
  • ACOG, 2018
    ACOG Committee Opinion No. 742: Postpartum Pain Management
  • CPIC, 2014
    Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update. (See 2021 Update)
  • CPNDS, 2013
    Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy.
  • CPIC, 2012
    Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype (See 2021 Update)
  • DPWG, 2011
    Pharmacogenetics: from bench to byte--an update of guidelines.

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.