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GTR Home > Tests > DCMNext®

DCMNext®

  • GTR Test IDHelp: GTR000560529.9
  • Last updated: 2023-04-07
  • Test version history

Clinical testHelp for Dilated cardiomyopathy 1A
Offered by Ambry Genetics

Indication

This is a clinical test intended for Help: Diagnosis, Pre-symptomatic

Clinical summary

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Imported from GeneReviews

LMNA-related dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and/or reduced systolic function preceded (sometimes by many years) by or accompanied by conduction system disease and/or arrhythmias. LMNA-related DCM usually presents in early to mid-adulthood with symptomatic conduction system disease or arrhythmias, or with symptomatic DCM including heart failure or embolus from a left ventricular mural thrombus. Sudden cardiac death can occur, and in some instances is the presenting manifestation; sudden cardiac death may occur with minimal or no systolic dysfunction.

Clinical features

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Imported from Human Phenotype Ontology (HPO)

  • Atrial fibrillation
  • Atrial flutter
  • Primary dilated cardiomyopathy
  • Congestive heart failure
  • Pericardial effusion
  • Sudden cardiac death
  • Sinus bradycardia
  • Ventricular arrhythmia
  • First degree atrioventricular block
  • Third degree atrioventricular block
  • Second degree atrioventricular block
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Inheritance pattern

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Autosomal dominant inheritance

Conditions tested

Target population

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Not provided

Clinical validity

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Clinical validity depends on specific clinical and family history.

Citations

Not provided

Clinical utility

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Not provided

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