High-Resolution Rapid Microarray (CGH and SNP)
- GTR Test IDHelpEach Test is a specific, orderable test from a particular laboratory, and is assigned a unique GTR accession number. The format is GTR00000001.1, with a leading prefix 'GTR' followed by 8 digits, a period, then 1 or more digits representing the version. When a laboratory updates a registered test, a new version number is assigned.: GTR000560671.2
- Last updated: 2023-05-18
- Test version history
Clinical testHelpIn the U.S., clinical tests must be performed under CLIA certification. When a lab uses the same methods for a test in both clinical and research settings, the test appears as two separate GTR records. for Congenital chromosomal disease
Offered by Allele Diagnostics
Overview
Test name
HelpThe name the laboratory assigns the test. Used as the default title of the page specific to the test.High-Resolution Rapid Microarray (CGH and SNP)
This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Diagnosis
Click Indication tab for more information.
For specimen requirements and handling instructions please visit: https://www.allelediagnostics.com/ordering/sample-requirements/. Allele Diagnostics accepts samples Monday-Saturday excluding some holidays. Contact Allele Diagnostics regarding holiday schedules. Please include a complete copy of the appropriate Allele Diagnostics Requisition form: https://www.allelediagnostics.com/ordering/requisition/.
Order URL HelpLink to the laboratory webpage with information about how to order this test. Please note that clicking on this link will open a new tab in your internet browser.: https://www.allelediagnostics.com/ordering/order-test/
Specimen source
Methodology
HelpThe assay's major method category (biochemical, cytogenetic or molecular genetics); method category (i.e. enzyme assay, chromosome breakage studies, targeted mutation analysis); methodology (i.e. the name of the method used) and instruments used when performing this test.- Molecular Genetics
- DDeletion/duplication analysis
- Comparative Genomic Hybridization
- HDetection of homozygosity
- SNP Detection
Guidance for management
- Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies. - PubMed ID: 22865506
- Clinical utility of chromosomal microarray analysis. - PubMed ID: 23071206
- Committee Opinion No. 581: the use of chromosomal microarray analysis in prenatal diagnosis. - PubMed ID: 24264715
Establish or confirm diagnosis
- Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies. - PubMed ID: 22865506
- Chromosomal microarray versus karyotyping for prenatal diagnosis. - PubMed ID: 23215555
- Committee Opinion No. 581: the use of chromosomal microarray analysis in prenatal diagnosis. - PubMed ID: 24264715
Reproductive decision-making
- Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies. - PubMed ID: 22865506
- Chromosomal microarray versus karyotyping for prenatal diagnosis. - PubMed ID: 23215555
- Committee Opinion No. 581: the use of chromosomal microarray analysis in prenatal diagnosis. - PubMed ID: 24264715
Clinical validity
HelpHow consistently and accurately the test detects or predicts the intermediate or final outcomes of interest. Lab-provided.Not provided
Testing strategy
HelpThe lab's suggested sequence of ordering tests based on clinical scenarios. It may include information on: reflex testing including each test component, and scenarios which prompt additional components of testing; whether lab communicates interim results or automatically proceeds to further analyses; and if any components are performed in another laboratory.Microarray analysis reported within 2-4 business days if specimen is adequate. If not adequate, client will be contacted and plan established. After identification of a copy number gain or loss, FISH confirmation/visualization is attempted for majority of findings if specimen is adequate. If parental specimens are submitted with prenatal specimen, they are stabilized and available for follow-up testing after FISH is completed on prenatal sample. 000 For specimen requirements and handling instructions please visit: https://www.allelediagnostics.com/ordering/sample-requirements/. Allele Diagnostics accepts samples Monday-Saturday excluding some holidays. Contact Allele Diagnostics regarding holiday schedules. Please include a complete copy of the appropriate Allele Diagnostics Requisition form: https://www.allelediagnostics.com/ordering/requisition/.
Test services
HelpLaboratory's order or catalog code for the test (used in the order requisition form).- Custom Balanced Chromosome Rearrangement Studies, commentsAfter identification of a copy number gain or loss, FISH confirmation/visualization is attempted for majority of findings if specimen is adequate.
- Maternal cell contamination study (MCC), Order code: 7500, commentsMaternal cell contamination studies are recommended but not required for all prenatal microarrays.
- Cell culturing, commentsBackup cell culturing performed with all prenatal microarrays. CPT code 88233 for POC, 88235 for amnio or CVS.
- Custom Deletion/Duplication Testing, commentsAfter identification of a copy number gain or loss, FISH confirmation/visualization is attempted for majority of findings if specimen is adequate.
- NSGC, 2021National Society of Genetic Counselors Position Statement: Prenatal Cell-Free DNA Screening
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