Pharmacogenomics Test Panel

GTR Test IDHelpEach Test is a specific, orderable test from a particular laboratory, and is assigned a unique GTR accession number. The format is GTR00000001.1, with a leading prefix 'GTR' followed by 8 digits, a period, then 1 or more digits representing the version. When a laboratory updates a registered test, a new version number is assigned.: GTR000571275.2
Last updated: 2023-01-12
Test version history
- 571275.2, last updated: 2023-01-12
- 571275.1, last updated: 2021-01-15

Clinical testHelpIn the U.S., clinical tests must be performed under CLIA certification. When a lab uses the same methods for a test in both clinical and research settings, the test appears as two separate GTR records. for Efavirenz response
Offered by IU Genetic Testing Laboratories

Indication

This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Drug Response

Imported from PharmGKB

Efavirenz is a non-nucleoside reverse transcriptase inhibitor widely used worldwide to treat HIV-1 infection. It is predominantly metabolized into inactive metabolites by cytochrome P450-2B6 (CYP2B6). Genetic variants in CYP2B6 (e.g. CYP2B6*6 and *18), along with other genetic and non-genetic factors, are known to influence variability in efavirenz response. Patients with certain CYP2B6 genetic polymorphisms may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation.

Conditions tested

Information about genotype may be used as an aid to clinicians in determining therapeutic strategy and treatment dose for therapeutics

Citations

Not provided

Reviews

Clinical resources

Practice guidelines

PAGAA, 2020
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services.
DailyMed Drug Label, 2020
DailyMed Drug Label, SUSTIVA- efavirenz, 2020

Molecular resources

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.