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GTR Home > Tests > Colorectal Cancer Panel

Indication

This is a clinical test intended for Help: Diagnosis, Predictive, Prognostic

Clinical summary

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Imported from GeneReviews

Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.

Clinical features

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Imported from Human Phenotype Ontology (HPO)

  • Renal cell carcinoma
  • Neoplasm of stomach
  • Transitional cell carcinoma of the bladder
  • Uterine leiomyosarcoma
  • Hereditary nonpolyposis colorectal carcinoma

Inheritance pattern

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Somatic mutation , Sporadic

Conditions tested

Target population

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Patient with family history

Citations

Not provided

Clinical validity

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99.99

Citations

Not provided

Clinical utility

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Establish or confirm diagnosis

Predictive risk information for patient and/or family members

Lifestyle planning

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.