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GTR Home > Tests > Mismatch Repair Proteins by Immunohistochemistry

Overview

Test order codeHelp: IHC for MLH1, MSH2, MSH6, PMS2

Test name

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Mismatch Repair Proteins by Immunohistochemistry (MMR IHC)

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Screening

Condition

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Click Indication tab for more information.

How to order

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use the IHC requisition form and select the proteins you want stained by IHC CPT codes are 88342 x1, and 88341 x3
Order URL Help: http://www.gopathlabs.com/contact_us/

Specimen source

Fresh tissue
Frozen tissue
Paraffin block

Methodology

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Biochemical Genetics
IImmunohistochemistry
Antibody detection
  • LABVISION 360 AUTOSTAINER
  • None/not applicable

Summary of what is tested

Click Methodology tab for more information.

Clinical utility

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Not provided

Clinical validity

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Not provided

Test services

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  • Immunohistochemistry, Order code: 88342x1, 88341x3

Suggested reading

Practice guidelines

  • EHTG/ESCP, 2021
    European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
  • ACMG, 2016
    Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.
  • ASCO, 2015
    American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility
  • Mork et al., 2015
    Lynch Syndrome: A Primer for Urologists and Panel Recommendations.
  • ACG, 2015
    ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
  • ASCO/ESMO, 2015
    Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines.
  • ACMG, 2015
    ACMG policy statement: updated recommendations regarding analysis and reporting of secondary findings in clinical genome-scale sequencing.
  • MSTF, 2014
    Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer.
  • ASCO, 2014
    American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.
  • SGO, 2014
    Society of Gynecologic Oncology (SGO) Clinical Practice Statement: Screening for Lynch Syndrome in Endometrial Cancer
  • ACMG, 2014
    ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis).
  • ACMG, 2013
    ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.
  • Dutch SCG, 2013
    Informing family members of individuals with Lynch syndrome: a guideline for clinical geneticists.
  • Mallorca group, 2013
    Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. (See EHTG/ESCP, 2021 Update)
  • CAPS, 2013
    International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer (See 2020 Update)
  • EGAPP, 2009
    Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives
  • NSGC, 2004
    Genetic cancer risk assessment and counseling: recommendations of the National Society of Genetic Counselors. (Retired following 2012 Update)
  • ASCRS, 2001
    Practice parameters for the identification and testing of patients at risk for dominantly inherited colorectal cancer--supporting documentation.

Consumer resources

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