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Brain Cancer Profile
Clinical Genetic Test
Help
offered by
GoPath Diagnostics
View lab's test page
LinkOut
GTR Test Accession: Help GTR000591183.1
CANCERNERVOUS SYSTEM
Last updated in GTR: 2020-07-06
View version history
Last annual review date for the lab: 2023-06-14 LinkOut
At a Glance
Test purpose: Help
Therapeutic management
Conditions (1): Help
Glioblastoma
Proteins (1): Help
DNA alkytransferase
Methods (2): Help
Molecular Genetics - Methylation analysis: PCR; ...
Target population: Help
patients with glioblastoma who receive alkylating agents for chemotherapy
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
GoPath Diagnostics
View lab's website
View lab's test page
Test short name: Help
BRAIN94
Specimen Source: Help
Who can order: Help
  • Health Care Provider
  • Licensed Physician
Test Order Code: Help
Brain Profile
CPT codes: Help
**AMA CPT codes notice

Copyright: 2023 American Medical Association. All rights reserved.

Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
download PDF requisition online and contact our customer service to coordinate on how to send sample

CPT codes : 81210, 81275, 81276, 81311, 81120
Order URL
Test service: Help
PCR
Test development: Help
Manufactured (research use only; not FDA-reviewed)
Informed consent required: Help
No
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Lab contact for this test, Test strategy
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Proteins Help
Total proteins: 1
Protein Associated Condition
Methodology
Total methods: 2
Method Category Help
Test method Help
Instrument
Methylation analysis
PCR
ABI9700 GeneAmp PCR system
Sequence analysis of the entire coding region
PCR
ABI9700 GeneAmp PCR System
Clinical Information
Test purpose: Help
Therapeutic management
Target population: Help
patients with glioblastoma who receive alkylating agents for chemotherapy
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
Interpretation and classification of clinical significance of the detected variant are based on catalogued information from the NCBI ClinVar database (http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/clinvar/variation/), LOVD database (http://databases.lovd.nl/ shared/genes/) and other locus specific databases as well as information from published literatures

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
Yes.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Not provided. our GeneticsNow service covers it all - please use our website www.gopathlabs.com
Recommended fields not provided:
Clinical validity, Clinical utility, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Test Platform:
ABI 3130 XL Genetic Analyzer
Availability: Help
Tests performed
Entire test performed in-house

Test performance comments
the only part of this test that is sent out is the 1p/19q deletion (FISH) - so this test and procedure is not listed in the panel
Analytical Validity: Help
MGMT: Sensitivity of the assay was determined by the detection of serially diluted in vitro methylated MGMT DNA sequence in the background of un-methylated DNA sequences. In vitro methylated normal lymphocyte DNA was proportionally diluted into 100%, 80%, 60%, 20% and 10% using un-methylated normal lymphocyte DNA and bisulfite DNA … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
CAP
VUS:
Software used to interpret novel variations Help
NextGENe

Laboratory's policy on reporting novel variations Help
formal reports
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.