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LYNCHnow Extended
Clinical Genetic Test
Help
offered by
GoPath Diagnostics
GTR Test Accession: Help GTR000591263.1
INHERITED DISEASEINHERITED DISEASE SUSCEPTIBILITYCANCER ... View more
Last updated in GTR: 2020-07-28
View version history
Last annual review date for the lab: 2023-06-14 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Predictive; Prognostic; ...
Conditions (1): Help
Lynch syndrome
Genes (5): Help
EPCAM (2p21), MLH1 (3p22.2), MSH2 (2p21-16.3), MSH6 (2p16.3), PMS2 (7p22.1)
Methods (1): Help
Molecular Genetics - Sequence analysis of the entire coding region: PCR
Target population: Help
patients who have a family history of colon cancer and …
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
GoPath Diagnostics
View lab's website
Test short name: Help
LYNCH
Specimen Source: Help
Who can order: Help
  • Health Care Provider
  • Licensed Physician
  • Nurse Practitioner
  • Physician Assistant
Test Order Code: Help
LYNCH
CPT codes: Help
**AMA CPT codes notice

Copyright: 2023 American Medical Association. All rights reserved.

Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
contact gopath labs to review ordering instructions and coordination for genetic counseling
contact vengelmann@gopathlabs.com for LYNCH testing and coordinate genetic counseling
Order URL
Test service: Help
Custom Deletion/Duplication Testing
    Comment: LYNCHnow
Informed consent required: Help
Yes
Pre-test genetic counseling required: Help
Yes
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Lab contact for this test, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 5
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument
Sequence analysis of the entire coding region
PCR
Illumina Miseq NGS sequencer
Clinical Information
Test purpose: Help
Diagnosis; Predictive; Prognostic; Risk Assessment; Screening; Therapeutic management
Target population: Help
patients who have a family history of colon cancer and patients with colon cancer who could benefit from treatment based on if they have a pathogenic mutation
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
Interpretation and classification of clinical significance of the detected variant are based on catalogued information from the NCBI ClinVar database (http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/clinvar/variation/), LOVD database (http://databases.lovd.nl/ shared/genes/) and other locus specific databases as well as information from published literatures

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
Yes.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Yes. our GeneticsNow service covers it all - please use our website www.gopathlabs.com
Recommended fields not provided:
Clinical validity, Clinical utility, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Test Platform:
NextGene
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Sensitivity 100% PPV 100% NPV 100% LOD 10% Accuracy 100% Precision 6.8%
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
CAP
VUS:
Software used to interpret novel variations Help
NextGENe

Laboratory's policy on reporting novel variations Help
formal reports
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.