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GTR Home > Tests > Chromosome Analysis, Tissue (Postnatal, POC, or Autopsy)

Overview

Test order codeHelp: TCS

Test name

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Chromosome Analysis, Tissue (Postnatal, POC, or Autopsy) (Tissue chromosome anaysis, POC chromosome analysis, Autopsy chro)

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Risk Assessment

Condition

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Click Indication tab for more information.

How to order

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Submit a sample with a completed requisition form. Label sample and form with at least two patient identifying information, such as name and date of birth. If POC sample from pregnancy loss (non-viable pregnancy), please label sample and form with mother's ID.
Order URL Help: https://www.nationwidechildrens.org/specialties/laboratory-services

Specimen source

Fresh tissue
Product of conception (POC)
Skin

Methodology

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Cytogenetics
KKaryotyping
G-banding

Summary of what is tested

Click Methodology tab for more information.

Clinical utility

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Not provided

Clinical validity

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Not provided

Testing strategy

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Reflex to microarray analysis available 000 Submit a sample with a completed requisition form. Label sample and form with at least two patient identifying information, such as name and date of birth. If POC sample from pregnancy loss (non-viable pregnancy), please label sample and form with mother's ID.

Test services

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  • Custom Balanced Chromosome Rearrangement Studies, comments
  • Custom Deletion/Duplication Testing, comments
  • Mosaicism Study (Extended Cell Count, 50-Cell Study), comments
  • Cryopreservation of Cultured Cells, comments

Practice guidelines

  • ACMG, 2021
    Chromosomal microarray analysis, including constitutional and neoplastic disease applications, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
  • NSGC, 2021
    National Society of Genetic Counselors Position Statement: Prenatal Cell-Free DNA Screening
  • ACMG, 2016
    Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics
  • ESHG/ASHG, 2015
    Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.
  • NSGC, 2013
    Noninvasive prenatal testing/noninvasive prenatal diagnosis: the position of the National Society of Genetic Counselors. (Replaced by NSCG, 2021 Statement)
  • ACMG, 2013
    ACMG statement on noninvasive prenatal screening for fetal aneuploidy. (See 2016 Update)
  • ICFMM, 2013
    Position Statement from the Italian College of Fetal Maternal Medicine: Non-invasive prenatal testing (NIPT) by maternal plasma DNA sequencing.
  • NSGC, 2013
    NSGC practice guideline: prenatal screening and diagnostic testing options for chromosome aneuploidy.

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.