U.S. flag

An official website of the United States government

GTR Home > Tests > Psych HealthPGx Panel

Overview

Test order codeHelp: Psych HealthPGx Panel

Test name

Help

Psych HealthPGx Panel (Psych panel)

Purpose of the test

Help

This is a clinical test intended for Help: Drug Response, Predictive, Risk Assessment, Therapeutic management

Condition

Help

Click Indication tab for more information.

How to order

Help

Acceptable specimen sources are blood, extracted DNA (gDNA), saliva and buccal swab. Peripheral Whole Blood: 3-5mL in EDTA tube (lavender top). This is our preferred specimen type; Extracted DNA: 1ug DNA (please indicate sample source on test request form); Saliva: Use DNA Genotek Oragene DNA (OG-500) kit. Buccal swab: Collect using Copan hDNAFree FLOQSwabs (Cat# 50E010D01) or IsoHelix RapiDri Buccal swab with self-drying pouch (Cat# RD-01) according to manufacturer’s instructions. All samples should be shipped Sunday through Thursday (next day delivery only). Contact for availability of alternative shipping schedules and additional shipping requirements. Shipping is acceptable at ambient or refrigerated temperature. Any blood samples collected and not shipped immediately should be refrigerated and shipped overnight as soon as possible (less than 5-7 days after collection) to ensure specimen stability and quality.
Order URL Help: https://www.rprdx.com/testing/how-it-works/

Specimen source

Buccal swab
Isolated DNA
Peripheral (whole) blood
Saliva

Methodology

Help
Molecular Genetics
DDeletion/duplication analysis
Microarray
  • Affymetrix GeneTitan® MC
  • Affymetrix Gene Profiling Array cGMP U133 P2
TTargeted variant analysis
Microarray
  • Affymetrix GeneTitan® MC
  • Affymetrix Gene Profiling Array cGMP U133 P2
PCR
  • Other
  • Affymetrix Gene Profiling Array cGMP U133 P2

Summary of what is tested

Click Methodology tab for more information.

Clinical utility

Help

Guidance for selecting a drug therapy and/or dose

Citations
  • A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. - PubMed ID: 22990750
  • Development and use of active clinical decision support for preemptive pharmacogenomics. - PubMed ID: 23978487
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. - PubMed ID: 25974703
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. - PubMed ID: 32770672

Pre-emptive clinical implementation

Citations
  • PG4KDS: a model for the clinical implementation of pre-emptive pharmacogenetics. - PubMed ID: 24619595

Clinical validity

Help

To determine the diagnostic sensitivity, we utilized the manufacturer’s recommended input concentration and analysis QC thresholds. We demonstrated adherence to our validation threshold (i.e. ≥ 95% sensitivity) in detection of true positive results, with a false negative rate of ≤ 5%. To determine the diagnostic specificity, we utilized the manufacturer’s recommended input concentration and analysis QC thresholds. The PharmacoScan™ Assay demonstrated ≥ 99% sensitivity in detecting the correct genotypes of each sample tested.

Citations

Testing strategy

Help

This test ideally is utilized pre-emptively (prior to receiving drug medication) or as a reflex testing when an adverse reaction to a medication has been observed. 000 Acceptable specimen sources are blood, extracted DNA (gDNA), saliva and buccal swab. Peripheral Whole Blood: 3-5mL in EDTA tube (lavender top). This is our preferred specimen type; Extracted DNA: 1ug DNA (please indicate sample source on test request form); Saliva: Use DNA Genotek Oragene DNA (OG-500) kit. Buccal swab: Collect using Copan hDNAFree FLOQSwabs (Cat# 50E010D01) or IsoHelix RapiDri Buccal swab with self-drying pouch (Cat# RD-01) according to manufacturer’s instructions. All samples should be shipped Sunday through Thursday (next day delivery only). Contact for availability of alternative shipping schedules and additional shipping requirements. Shipping is acceptable at ambient or refrigerated temperature. Any blood samples collected and not shipped immediately should be refrigerated and shipped overnight as soon as possible (less than 5-7 days after collection) to ensure specimen stability and quality.

Test services

Help
  • Pharmacogenetics

Practice guidelines

  • DailyMed Drug Label, 2021
    DailyMed Drug Label, AMITRIPTYLINE HYDROCHLORIDE, 2021
  • CPIC, 2017
    Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update
  • CPIC, 2013
    Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. (See 2016 Update)
  • DailyMed Drug Label, 2012
    DailyMed Drug Label, amitriptyline, 2012
  • DPWG, 2011
    Pharmacogenetics: from bench to byte--an update of guidelines.

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.