OncoAlly™ Cancer Predisposition
Clinical Genetic Test
Help
offered by
GTR Test Accession: Help GTR000603514.2
INHERITED DISEASEINHERITED DISEASE SUSCEPTIBILITYCANCER ... View more
Last updated in GTR: 2023-05-23
Last annual review date for the lab: 2024-01-30 LinkOut
At a Glance
Diagnosis
Hereditary cancer; Hereditary cancer-predisposing syndrome
APC (5q22.2), ATM (11q22.3), AXIN2 (17q24.1), BAP1 (3p21.1), BARD1 (2q35), ...
Molecular Genetics - Deletion/duplication analysis: Next-Generation (NGS)/Massively parallel sequencing (MPS); ...
Not provided
Not provided
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Ordering Information
Offered by: Help
Specimen Source: Help
Who can order: Help
  • Health Care Provider
Test Order Code: Help
CPT codes: Help
**AMA CPT codes notice
Lab contact: Help
Christine Stanley, PhD, FACMG, Medical Director
christine.stanley@variantyx.com
+1 617-209-2090
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Informed consent required: Help
Yes
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 2
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 87
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 3
Method Category Help
Test method Help
Instrument *
Deletion/duplication analysis
Next-Generation (NGS)/Massively parallel sequencing (MPS)
Mutation scanning of select exons
Next-Generation (NGS)/Massively parallel sequencing (MPS)
Sequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
Variants are classified using one of five interpretation categories recommended by the American College of Medical Genetics and Genomics (ACMG): pathogenic, likely pathogenic, uncertain, likely benign, and benign (PMID: 25741868, 31690835). Pathogenic, likely pathogenic and variants of uncertain clinical significance are reported. Benign and likely benign variants are typically not … View more

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Not provided.
Recommended fields not provided:
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Whole genome sequencing (WGS) methodology provides comprehensive access to an individual’s genome including coverage of coding as well as non-coding regions. Whole genome sequencing identifies small sequence changes including single nucleotide variants (SNVs) and small insertions and deletions (Indels) as well as large structural variants including large duplications and deletions.The … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Intra-Laboratory
VUS:
Software used to interpret novel variations Help
Proprietary Variantyx Genomic Intelligence platform
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.