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GTR Home > Tests > MSH6

Overview

Test order codeHelp: MSH6

Test name

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MSH6

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Predictive

Condition

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How to order

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Not provided

Specimen source

Peripheral (whole) blood
Frozen tissue
Amniotic fluid
Chorionic villi
Paraffin block
Buccal swab
Skin
Fresh tissue
Fibroblasts
Isolated DNA
Fetal blood
Saliva
Amniocytes
Cord blood

Methodology

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Molecular Genetics
IMicrosatellite instability testing (MSI)
gMSI
SMutation scanning of the entire coding region
Bi-directional Sanger Sequence Analysis
CSequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)

Summary of what is tested

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Clinical utility

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Not provided

Clinical validity

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Not provided

Practice guidelines

  • NICE, 2021
    UK NICE Guideline NG151, Colorectal cancer, 2021
  • NICE, 2020
    UK NICE Diagnostics Guidance DG42, Testing strategies for Lynch syndrome in people with endometrial cancer, 2020
  • ACMG ACT, 2019
    American College of Medical Genetics and Genomics, Genomic Testing (Secondary Findings) ACT Sheet, MLH1, MSH2, MSH6, PMS2, EPCAM Pathogenic Variants, Lynch Syndrome (Hereditary Non-polyposis Colon Cancer [HNPCC]), 2019

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.