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HomoloGene:111129. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SERPINA3,  H.sapiens
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NP_001076.2
423 aa
SERPINA3,  P.troglodytes
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
XP_510145.2
448 aa
SERPINA3,  M.mulatta
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
XP_001096947.2
448 aa
SERPINA3,  C.lupus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
XP_005623829.1
421 aa
SERPINA3-7,  B.taurus
endopin 2
NP_001012283.2
417 aa
LOC784932,  B.taurus
serpin A3-7-like
XP_002696874.1
417 aa
SERPINA3-8,  B.taurus
SERPINA3-8
NP_001075181.1
418 aa
SERPINA3-1,  B.taurus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NP_777193.2
411 aa
SERPINA3-3,  B.taurus
endopin 1b
NP_001033293.1
411 aa
SERPINA3,  B.taurus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
XP_005222351.1
412 aa
Serpina3n,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 3N
NP_033278.2
418 aa
Serpina3c,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 3C
NP_032484.1
417 aa
Serpina3m,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 3M
NP_033279.2
418 aa
Serpina3k,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 3K
NP_035588.2
418 aa
Serpina3n,  R.norvegicus
serine (or cysteine) peptidase inhibitor, clade A, member 3N
NP_113719.1
408 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alpha-1-antichymotrypsin deficiency.
Cerebrovascular disease, occlusive.



Publications
Articles associated with genes and sequences of this homology group.

PSA forms complexes with α1-antichymotrypsin in prostate.
Zhu L, et al. Prostate 73, 219-26 (2013).
alpha(1)-Antichymotrypsin deficiency associated with liver cirrhosis.
Ortega L, et al. Pediatr Int 52, 147-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SERPIN (cl00137)
  SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
SERPIN (cl00137)
  SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Serpina3n includes H.sapiens SERPINA3 and R.norvegicus Serpina3n.

 

 

 

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