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HomoloGene:123820. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

HLA-DQA1,  H.sapiens
major histocompatibility complex, class II, DQ alpha 1
255 aa
PATR-DQA1,  P.troglodytes
major histocompatibility complex, class II, DQ alpha 1
255 aa
HLA-DQA1,  M.mulatta
major histocompatibility complex, class II, DQ alpha 1-like
254 aa
MAMU-DQA1,  M.mulatta
major histocompatibility complex, class II, DQ alpha 1
255 aa
LOC100848815,  B.taurus
SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like
255 aa
H2-Aa,  M.musculus
histocompatibility 2, class II antigen A, alpha
256 aa
RT1-Ba,  R.norvegicus
RT1 class II, locus Ba
255 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Celiac disease, susceptibility to.

Articles associated with genes and sequences of this homology group.

HLA class II locus and susceptibility to podoconiosis.
Tekola Ayele F, et al. N Engl J Med 366, 1200-8 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MHC_II_alpha (cl03058)
  Class II MHC glycoproteins are expressed on the surface of antigen-presenting cells (APC), including macrophages, dendritic cells and B cells. MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and inflammatory T cells (cause the release of lymphokines that attract other cells to site of infection).
Ig (cl11960)
  Immunoglobulin domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus H2-Aa includes H.sapiens HLA-DQA1 and R.norvegicus RT1-Ba.




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