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HomoloGene:32395. Gene conserved in Boreoeutheria

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	PLEKHG6, H.sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 6			NP_060643.2 790 aa
	PLEKHG6, P.troglodytes pleckstrin homology domain containing, family G (with RhoGef domain) member 6			XP_522333.2 790 aa
	PLEKHG6, M.mulatta pleckstrin homology domain containing, family G (with RhoGef domain) member 6			XP_001118229.2 781 aa
	PLEKHG6, C.lupus pleckstrin homology domain containing, family G (with RhoGef domain) member 6			XP_534913.2 800 aa
	PLEKHG6, B.taurus pleckstrin homology domain containing, family G (with RhoGef domain) member 6			XP_003586191.1 789 aa
	Plekhg6, M.musculus pleckstrin homology domain containing, family G (with RhoGef domain) member 6			NP_941006.2 787 aa
	Plekhg6, R.norvegicus pleckstrin homology domain containing, family G (with RhoGef domain) member 6			XP_006237465.1 783 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle. Asiedu M, et al. J Biol Chem 283, 28392-400 (2008).
Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. D'Angelo R, et al. Mol Biol Cell 18, 4780-93 (2007).
A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis. Wu D, et al. Cell Cycle 5, 1234-9 (2006).
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Wu D, et al. Oncogene 28, 2219-30 (2009).
Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Asiedu M, et al. Mol Biol Cell 20, 1428-40 (2009).
GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. Wu D, et al. J Biol Chem 285, 28643-50 (2010).
Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, et al. Gene Expr Patterns 3, 375-81 (2003).

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
RhoGEF (cl02571) Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
PH-like (cl17171) Pleckstrin homology-like domain.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:2682298 Orthology group for M.musculus Plekhg6 includes H.sapiens PLEKHG6.

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