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HomoloGene:68367. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GMPS,  H.sapiens
guanine monphosphate synthase
NP_003866.1
693 aa
GMPS,  P.troglodytes
guanine monphosphate synthetase
XP_003310106.1
693 aa
GMPS,  M.mulatta
guanine monphosphate synthetase
XP_001105046.1
693 aa
GMPS,  C.lupus
guanine monphosphate synthase
XP_534316.2
725 aa
GMPS,  B.taurus
guanine monphosphate synthetase
NP_001193365.1
699 aa
Gmps,  M.musculus
guanine monophosphate synthetase
NP_001028472.2
693 aa
Gmps,  R.norvegicus
guanine monphosphate synthase
NP_001019925.1
693 aa
GMPS,  G.gallus
guanine monphosphate synthetase
NP_001006556.1
693 aa
gmps,  X.tropicalis
guanine monphosphate synthetase
XP_002933290.2
763 aa
gmps,  D.rerio
guanine monphosphate synthetase
NP_956881.2
692 aa
bur,  D.melanogaster
burgundy
NP_620114.3
683 aa
AgaP_AGAP010139,  A.gambiae
AgaP_AGAP010139
XP_319294.4
679 aa
M106.4,  C.elegans
M106.4
NP_001076631.1
709 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, acute myelogenous.



Publications
Articles associated with genes and sequences of this homology group.

Biochemical characterization of human GMP synthetase.
Nakamura J & Lou L. J Biol Chem 270, 7347-53 (1995).
Enzymes of purine metabolism in cancer.
Weber G. Clin Biochem 16, 57-63 (1983).
Human GMP synthetase.
Page T, et al. Int J Biochem 16, 117-20 (1984).
Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin.
Prajda N, et al. Biochem Pharmacol 37, 875-80 (1988).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GMP_synt_C (pfam00958)
  GMP synthase C terminal domain.
AANH_like (cl00292)
  Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
GAT_1 (cl00020)
  Type 1 glutamine amidotransferase (GATase1)-like domain.
AANH_like (cl00292)
  Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gmps includes H.sapiens GMPS and R.norvegicus Gmps.

 

 

 

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