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HomoloGene:7756. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HEY1,  H.sapiens
hes-related family bHLH transcription factor with YRPW motif 1
NP_036390.3
304 aa
HEY1,  P.troglodytes
hairy/enhancer-of-split related with YRPW motif 1
XP_519823.2
304 aa
HEY1,  M.mulatta
hairy/enhancer-of-split related with YRPW motif 1
XP_001090360.2
308 aa
HEY1,  C.lupus
hairy/enhancer-of-split related with YRPW motif 1
NP_001002953.1
304 aa
HEY1,  B.taurus
hairy/enhancer-of-split related with YRPW motif 1
NP_001001172.2
304 aa
Hey1,  M.musculus
hairy/enhancer-of-split related with YRPW motif 1
NP_034553.2
299 aa
Hey1,  R.norvegicus
hes-related family bHLH transcription factor with YRPW motif 1
NP_001178774.1
292 aa
HEY1,  G.gallus
hairy/enhancer-of-split related with YRPW motif 1
XP_425926.3
261 aa
hey1,  X.tropicalis
hes-related family bHLH transcription factor with YRPW motif 1
NP_001007911.1
300 aa
hey1,  D.rerio
hairy/enhancer-of-split related with YRPW motif 1
NP_997726.1
317 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

A role for the transcription factor HEY1 in glioblastoma.
Hulleman E, et al. J Cell Mol Med 13, 136-46 (2009).
Hey1, a mediator of notch signaling, is an androgen receptor corepressor.
Belandia B, et al. Mol Cell Biol 25, 1425-36 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Hairy_orange (pfam07527)
  Hairy Orange.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
Hairy_orange (cl02638)
  Hairy Orange.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hey1 includes H.sapiens HEY1 and R.norvegicus Hey1.

 

 

 

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