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HomoloGene:88343. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

KNG1,  H.sapiens
kininogen 1
644 aa
KNG1,  P.troglodytes
kininogen 1
644 aa
KNG1,  M.mulatta
kininogen 1
644 aa
KNG1,  C.lupus
kininogen 1
650 aa
KNG1,  B.taurus
kininogen 1
621 aa
Kng1,  M.musculus
kininogen 1
661 aa
Kng2,  M.musculus
kininogen 2
644 aa
Kng2,  R.norvegicus
kininogen 2
639 aa
KNG1,  G.gallus
kininogen 1
608 aa
kng1,  X.tropicalis
kininogen 1
588 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Fitzgerald factor deficiency.
High-molecular-weight kininogen deficiency.
Kininogen deficiency.

Articles associated with genes and sequences of this homology group.

KNG1 Ile581Thr and susceptibility to venous thrombosis.
Morange PE, et al. Blood 117, 3692-4 (2011).
Identification of lipopolysaccharide binding site on high molecular weight kininogen.
Perkins R, et al. Biochem Biophys Res Commun 366, 938-43 (2008).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Protamine_P2 (pfam00841)
  Sperm histone P2.
Epiglycanin_C (pfam14654)
  Mucin, catalytic, TM and cytoplasmic tail region.
CY (cl09238)
  Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
AAT_I (cl18945)
  Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kng1 includes H.sapiens KNG1 and R.norvegicus Kng1.




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