HomoloGene - NCBI

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HomoloGene:105490. Gene conserved in Boreoeutheria

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	CXCL2, H.sapiens chemokine (C-X-C motif) ligand 2			NP_002080.1 107 aa
	CXCL2, P.troglodytes chemokine (C-X-C motif) ligand 2			XP_001155614.1 107 aa
	CXCL2, M.mulatta chemokine (C-X-C motif) ligand 2			XP_001092240.1 107 aa
	CXCL3, B.taurus chemokine (C-X-C motif) ligand 3			NP_001039978.1 104 aa
	CXCL2, B.taurus chemokine (C-X-C motif) ligand 2			NP_776724.1 98 aa
	GRO1, B.taurus chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)			NP_783631.1 104 aa
	Cxcl1, M.musculus chemokine (C-X-C motif) ligand 1			NP_032202.1 96 aa
	Cxcl1, R.norvegicus chemokine (C-X-C motif) ligand 1			NP_110472.1 96 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer. Poluri KM, et al. J Biol Chem 288, 25143-25153 (2013).
CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction. Oral H, et al. J Mol Cell Cardiol 60, 1-7 (2013).
Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue. Rouault C, et al. Endocrinology 154, 1069-79 (2013).
Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans. Fischer A, et al. BMC Res Notes 5, 540 (2012).
CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction. Oue E, et al. Biochem Biophys Res Commun 424, 456-61 (2012).
CXCL1 regulation of oligodendrocyte progenitor cell migration is independent of calcium signaling. Vora P, et al. Exp Neurol 236, 259-67 (2012).
Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. Batra S, et al. J Immunol 188, 3458-68 (2012).
Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle. Pedersen L, et al. Am J Physiol Endocrinol Metab 302, E831-40 (2012).
Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma. Dong QM, et al. World J Gastroenterol 17, 2658-62 (2011).
Effect of a phytotherapeutic agent, Eviprostat®, on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis. Sugimoto M, et al. Prostate 71, 438-44 (2011).
See all (276)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Chemokine (cl00134) Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:108068 Orthology group for M.musculus Cxcl1 includes H.sapiens CXCL1 and R.norvegicus Cxcl1.

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