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HomoloGene:160. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	TBX5, H.sapiens T-box 5			NP_000183.2 518 aa
	TBX5, P.troglodytes T-box 5			XP_001154140.2 518 aa
	TBX5, M.mulatta T-box 5			XP_001111737.1 518 aa
	TBX5, C.lupus T-box 5			XP_005636327.1 519 aa
	TBX5, B.taurus T-box 5			NP_001179678.1 519 aa
	Tbx5, M.musculus T-box 5			NP_035667.1 518 aa
	Tbx5, R.norvegicus T-box 5			NP_001009964.1 517 aa
	TBX5, G.gallus T-box 5			NP_989504.1 521 aa
	tbx5, X.tropicalis T-box 5			NP_001185697.1 520 aa
	tbx5a, D.rerio T-box 5a			NP_570990.1 485 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:142900 Holt-Oram syndrome.

Publications Articles associated with genes and sequences of this homology group.
SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population. Zang X, et al. PLoS One 8, e64966 (2013).
Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects. Shan J, et al. Transl Res 160, 237-8 (2012).
Hox genes regulate the onset of Tbx5 expression in the forelimb. Minguillon C, et al. Development 139, 3180-8 (2012).
TBX5 intragenic duplication: a family with an atypical Holt-Oram syndrome phenotype. Patel C, et al. Eur J Hum Genet 20, 863-9 (2012).
[Holt-Oram syndrome: family affected without TBX5 mutation and without phenotype manifestations in a probable mutation carrier]. Murga-Eizagaechevarria N, et al. Rev Esp Cardiol 64, 1225-6 (2011).
Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. Yu J, et al. Oncogene 29, 6464-74 (2010).
Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form. Stirnimann CU, et al. J Mol Biol 400, 71-81 (2010).
Holt-Oram Syndrome McDermott DA, et al. (1993).
[The mechanism of TBX5 abnormal expression in simple congenital heart disease]. Xin N, et al. Yi Chuan 31, 374-80 (2009).
Association of TBX5 gene polymorphism with ventricular septal defect in the Chinese Han population. Liu CX, et al. Chin Med J (Engl) 122, 30-4 (2009).
See all (364)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
TBOX (cl00145) T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:102541 Orthology group for M.musculus Tbx5 includes H.sapiens TBX5 and R.norvegicus Tbx5.

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